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在活细胞状态下固定蛋白质-DNA复合物,并将其随机切断为一定长度范围内的染色质小片段,免疫学特异性地富集目的蛋白结合的DNA片段,通过对目的片断的纯化与检测,从而获得蛋白质与DNA相互作用的信息. 在活细胞状态下固定蛋白质-DNA复合物,并将其随机切断为一定长度范围内的染色质小片段,免疫学特异性地富集目的蛋白结合的DNA片段,通过对目的片断的纯化与检测,从而获得蛋白质与DNA相互作用的信息.